Journal article
Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in guinea pigs
EB King, JJ Hartsock, SJ O'Leary, AN Salt
Audiology and Neurotology | KARGER | Published : 2013
DOI: 10.1159/000353534
Abstract
Locally applied drugs can protect residual hearing following cochlear implantation. The influence of cochlear implantation on drug levels in the scala tympani (ST) after round window application was investigated in guinea pigs using the marker trimethylphenylammonium (TMPA) measured in real time with TMPA-selective microelectrodes. TMPA concentration in the upper basal turn of the ST rapidly increased during implantation and then declined due to cerebrospinal fluid entering the ST at the cochlear aqueduct and exiting at the cochleostomy. The TMPA increase was found to be caused by the cochleostomy drilling if the burr tip partially entered the ST. TMPA distribution in the second turn was les..
View full abstractRelated Projects (1)
Grants
Awarded by National Institutes of Health
Funding Acknowledgements
The authors would like to thank Ruth Gill for preparing the figures and Dr. Tim Hullar for his suggested experiments. This study was supported by NIH/NIDCD research grant DC01368 and the National Health and Medical Research Council of Australia project grant 1007948.